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Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 575-589 doi: 10.1007/s11684-019-0693-9

Abstract: Cartilage consists of both chondrocytes and extracellular matrix (ECM).The PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilageOur previous data have shown that DMP1-PG is richly expressed in the cartilaginous calluses of fractureHowever, the possible significant role of DMP1-PG in chondrogenesis and fracture healing is unknown.by using a glycosylation site mutant DMP1 mouse (S89G-DMP1 mouse).

Keywords： fracture     extracellular matrix     dentin matrix protein 1     proteoglycan     cartilage    

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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: The immune mapped protein 1 (NcIMP1) was identified as a membrane protein, and a previous study indicatedthat NcIMP1 could be a promising vaccine candidate against neosporosis.In this study, the immune response and protection efficacy of NcIMP1 were evaluated.responses against recombinant NcIMP1, with a mixed IgG1/IgG2a response and a predominance of IgG2a productionThe parasite burden was significantly reduced in the pcDNA-IMP1-vaccinated mice.

Keywords： Neospora caninum     immune mapped protein 1 (IMP1)     vaccine candidate     BALB/c mice    

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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependentfibrinolysis and matrix invasion in acute promyelocytic leukemia

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract: Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion proteinassociation between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion proteinZinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higherThus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 geneThe expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredWhen treated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatalMeanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Frontiers of Agricultural Science and Engineering   Pages 262-279 doi: 10.15302/J-FASE-2021383

Abstract: D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover     photoinhibition     photoprotection     photosynthesis     tomato     xanthophyll cycle    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plantsHere, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and highprotein production at both transcriptional and translational levels.Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition.

Keywords： D1 turnover / photoinhibition / photoprotection / photosynthesis / tomato / xanthophyll cycle    

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An improved subspace weighting method using random matrix theory Research Articles

Yu-meng Gao, Jiang-hui Li, Ye-chao Bai, Qiong Wang, Xing-gan Zhang,ychbai@nju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 9,   Pages 1302-1307 doi: 10.1631/FITEE.1900463

Abstract: Using the asymptotic results of the norm of the projection from the sample covariance matrix onto the

Keywords： Direction of arrival     Signal subspace     Random matrix theory    

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Programming bare-metal accelerators with heterogeneous threading models: a case study of Matrix-3000 Research Article

Jianbin FANG, Peng ZHANG, Chun HUANG, Tao TANG, Kai LU, Ruibo WANG, Zheng WANG,j.fang@nudt.edu.cn,zhangpeng13a@nudt.edu.cn,chunhuang@nudt.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 4,   Pages 509-520 doi: 10.1631/FITEE.2200359

Abstract: share our experience of developing a programming model and its supporting compiler and libraries for Matrixlow-level programming model offers native programming support for using the bare-metal accelerators of Matrix

Keywords： Heterogeneous computing     Parallel programming models     Programmability     Compilers     Runtime systems    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: Proteinase-activated receptors (PARs) are a novel subclass of seven transmembrane-spanning, G protein-coupledHowever, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Study on WBS matrix for construction management in urban rail-transi

Xie Lei1,Chen Qun,Yu Hua

Strategic Study of CAE 2010, Volume 12, Issue 1,   Pages 102-107

Abstract: rail-transit construction activities with a vertical breakdown of its technology system, thus a WBS matrixThis article firstly stated the concepts of interface and WBS matrix, with urban rail-transit analysisof how to use WBS matrix to improve interface management.The composition, structure system and principle of WBS matrix were specifically analyzed by contrastive

Keywords： urban rail-transit     WBS matrix     interface     interface management    

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A matrix-based static approach to analysis of finite state machines Research Article

He DENG, Yongyi YAN, Zengqiang CHEN,yyyan@mail.nankai.edu.cn

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 8,   Pages 1239-1246 doi: 10.1631/FITEE.2100561

Abstract: Traditional matrix-based approaches in the field of construct state transition matrices, and then useIn this study, we propose a static matrix-based approach that revisits a finite state machine from its

Keywords： Logical systems     Finite-valued systems     Semi-tensor product of matrices     Finite state machines     Matrix    

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proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: In particular, mouse Ly-6A/Sca-1 is a widely used marker for various stem cells; however, its human orthologWe cloned the full-length LY6A cDNA, whose encoded protein sequence, domain architecture, andexon‒intron structures are all well conserved with mouse Ly-6A/Sca-1.Ectopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca-1 in their processing and glycosylphosphatidylinositol anchoring to the cell membrane.

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymousSNP     GPI-anchored protein    

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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10−6) afterFurther bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissues, and its expression was related to the extracellular matrix (ECM) pathway.identified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1<

Keywords： sporadic thoracic aortic dissection     exome sequencing     gene COL3A1     case–control study     extracellularmatrix    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadbox protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liverOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedshort palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

Keywords： interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressedKaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictorOverexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdownof PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Title Author Date Type Operation

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Journal Article

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependentfibrinolysis and matrix invasion in acute promyelocytic leukemia

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER

Journal Article

An improved subspace weighting method using random matrix theory

Yu-meng Gao, Jiang-hui Li, Ye-chao Bai, Qiong Wang, Xing-gan Zhang,ychbai@nju.edu.cn

Journal Article

Programming bare-metal accelerators with heterogeneous threading models: a case study of Matrix-3000

Jianbin FANG, Peng ZHANG, Chun HUANG, Tao TANG, Kai LU, Ruibo WANG, Zheng WANG,j.fang@nudt.edu.cn,zhangpeng13a@nudt.edu.cn,chunhuang@nudt.edu.cn

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Study on WBS matrix for construction management in urban rail-transi

Xie Lei1,Chen Qun,Yu Hua

Journal Article

A matrix-based static approach to analysis of finite state machines

He DENG, Yongyi YAN, Zengqiang CHEN,yyyan@mail.nankai.edu.cn

Journal Article

proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1

Journal Article

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article